Expanded-Spectrum Nonnucleoside Reverse Transcriptase Inhibitors Inhibit Clinically Relevant Mutant Variants of Human Immunodeficiency Virus Type 1

• Published in: Antimicrobial Agents and Chemotherapy Vol. 43; no. 12; pp. 2893 - 2897
• Main Authors: Corbett, J W, Ko, S S, Rodgers, J D, Jeffrey, S, Bacheler, L T, Klabe, R M, Diamond, S, Lai, C M, Rabel, S R, Saye, J A, Adams, S P, Trainor, G L, Anderson, P S, Erickson-Viitanen, S K
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.12.1999; American Society for Microbiology (ASM)
• Subjects: AIDS/HIV; Amino Acid Substitution - genetics; Animals; Anti-HIV Agents; Anti-HIV Agents - pharmacokinetics; Anti-HIV Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Biological and medical sciences; Blood Proteins - metabolism; DPC082; DPC083; DPC961; DPC963; Half-Life; HIV Reverse Transcriptase; HIV Reverse Transcriptase - antagonists & inhibitors; HIV-1; HIV-1 - drug effects; HIV-1 - enzymology; HIV-1 - genetics; Human immunodeficiency virus 1; Humans; Macaca mulatta; Male; Medical sciences; Mutation; Mutation - physiology; Pan troglodytes; Pharmacology. Drug treatments; Protein Binding; Reverse Transcriptase Inhibitors; Reverse Transcriptase Inhibitors - pharmacokinetics; Reverse Transcriptase Inhibitors - pharmacology; Stereoisomerism; RNA-directed DNA polymerase; HIV-1 virus; Quinazoline derivatives; Monkey; Blood plasma; Structure activity relation; Primates; Antiviral; Human; Enzyme; Transferases; Oral administration; Retroviridae; Enzyme inhibitor; Serum protein; Lentivirus; Biological activity; Virus; Resistance; Nucleotidyltransferases; Vertebrata; Mammalia; Analog; Animal; Human immunodeficiency virus; Mutation; Pharmacokinetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.43.12.2893

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