Pharmacokinetics of [14C]Abacavir, a Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitor, Administered in a Single Oral Dose to HIV-1-Infected Adults: a Mass Balance Study

• Published in: Antimicrobial Agents and Chemotherapy Vol. 43; no. 12; pp. 2855 - 2861
• Main Authors: MCDOWELL, J. A, CHITTICK, G. E, RAVITCH, J. R, POLK, R. E, KERKERING, T. M, STEIN, D. S
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.12.1999
• Subjects: 5'-Carboxylate; 5'-Glucuronide; Abacavir; Adult; Anti-HIV Agents; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - cerebrospinal fluid; Anti-HIV Agents - pharmacokinetics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Biological and medical sciences; Chromatography, High Pressure Liquid; Dideoxynucleosides; Dideoxynucleosides - administration & dosage; Dideoxynucleosides - cerebrospinal fluid; Dideoxynucleosides - pharmacokinetics; Feces - chemistry; HIV Infections; HIV Infections - metabolism; HIV Reverse Transcriptase; HIV Reverse Transcriptase - antagonists & inhibitors; HIV-1; Human immunodeficiency virus 1; Humans; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Reverse Transcriptase Inhibitors; Reverse Transcriptase Inhibitors - administration & dosage; Reverse Transcriptase Inhibitors - cerebrospinal fluid; Reverse Transcriptase Inhibitors - pharmacokinetics; Spectrophotometry, Ultraviolet; Purine nucleoside; RNA-directed DNA polymerase; HIV-1 virus; Metabolite; Toxicity; Cerebrospinal fluid; Blood; Blood plasma; Antiviral; Radiopharmaceuticals; Labelled compound; Urine; Immunopathology; Enzyme; Transferases; Single dose; Elimination; Oral administration; Retroviridae; Enzyme inhibitor; AIDS; Metabolism; Immune deficiency; Lentivirus; Infection; Virus; Nucleotidyltransferases; Viral disease; Abacavir; Human immunodeficiency virus; Pharmacokinetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.43.12.2855

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