Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes

• Published in: Antimicrobial Agents and Chemotherapy Vol. 55; no. 10; pp. 4552 - 4559
• Main Authors: HIGHTOWER, Kendra E, WANG, Ruolan, SEKI, Takahiro, KOBAYASHI, Masanori, UNDERWOOD, Mark R, DEANDA, Felix, JOHNS, Brian A, WEAVER, Kurt, YINGNIAN SHEN, TOMBERLIN, Ginger H, LUKE CARTER, H, BRODERICK, Timothy, SIGETHY, Scott
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.10.2011
• Subjects: Amino Acid Substitution; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Biological and medical sciences; DNA, Complementary; DNA, Viral; DNA, Viral - metabolism; Drug Resistance, Viral; Genotype; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 3-Ring - metabolism; Heterocyclic Compounds, 3-Ring - pharmacology; HIV Integrase; HIV Integrase - genetics; HIV Integrase - metabolism; HIV Integrase Inhibitors; HIV Integrase Inhibitors - chemistry; HIV Integrase Inhibitors - metabolism; HIV Integrase Inhibitors - pharmacology; HIV-1; HIV-1 - drug effects; HIV-1 - genetics; Human immunodeficiency virus 1; Human viral diseases; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Medical sciences; Mutation; Pharmacology. Drug treatments; Pyrrolidinones; Pyrrolidinones - metabolism; Pyrrolidinones - pharmacology; Quinolones; Quinolones - metabolism; Quinolones - pharmacology; Raltegravir Potassium; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Immunopathology; Antiretroviral agent; HIV-1 virus; Retroviridae; Elvitegravir; AIDS; Wild type; Immune deficiency; Lentivirus; Infection; Virus; Resistance; Integrase inhibitor; Viral disease; DNA; Antiviral; Human immunodeficiency virus; Raltegravir
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.00157-11

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