Properties and Therapeutic Efficacy of Broadly Reactive Chimeric and Humanized H5-Specific Monoclonal Antibodies against H5N1 Influenza Viruses

• Published in: Antimicrobial Agents and Chemotherapy Vol. 55; no. 4; pp. 1349 - 1357
• Main Authors: Zheng, Qingbing, Xia, Lin, Wu, Wai Lan, Zheng, Zhenhua, Huo, Yongting, Wu, Jun, Liu, Yanning, Yu, Hai, Chen, Yixin, Lau, Siu-Ying, Chen, Honglin, Luo, Wenxin, Xia, Ningshao
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.04.2011; American Society for Microbiology (ASM)
• Subjects: Animal models; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antibodies, Monoclonal; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - therapeutic use; Antibodies, Viral; Antibodies, Viral - chemistry; Antibodies, Viral - immunology; Antibodies, Viral - therapeutic use; Antiviral Agents; Biological and medical sciences; CHO Cells; Cricetinae; Cricetulus; Enzyme-Linked Immunosorbent Assay; Hemagglutination inhibition; Human viral diseases; Humans; Immunogenicity; Infection; Infectious diseases; Influenza; Influenza A Virus, H5N1 Subtype; Influenza A Virus, H5N1 Subtype - immunology; Medical sciences; Mice; Models, Molecular; Monoclonal antibodies; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - prevention & control; Orthomyxoviridae Infections - virology; Peptide Library; Pharmacology. Drug treatments; Protein Structure, Secondary; Variable region; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Infection; Influenzavirus A(H5N1); Treatment; Viral disease; Treatment efficiency; Influenza; Monoclonal antibody; Chimerism
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.01436-10

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