Pharmacokinetics and Pharmacodynamics of TBR-652, a Novel CCR5 Antagonist, in HIV-1-Infected, Antiretroviral Treatment-Experienced, CCR5 Antagonist-Naïve Patients

• Published in: Antimicrobial Agents and Chemotherapy Vol. 55; no. 6; pp. 2768 - 2774
• Main Authors: MARIER, Jean-Francois, TRINH, Mymy, PHENG, Leng Hong, PALLEJA, Sandra M, MARTIN, David E
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.06.2011
• Subjects: Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome - drug therapy; Adult; Anti-HIV Agents; Anti-HIV Agents - pharmacokinetics; Anti-HIV Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral activity; Antiviral Agents; Azepines; Azepines - pharmacokinetics; Azepines - pharmacology; Biological and medical sciences; Blood; CCR5 protein; CCR5 Receptor Antagonists; Data processing; Dose-response effects; Dose-Response Relationship, Drug; Double-Blind Method; Female; HIV-1; Human immunodeficiency virus; Human immunodeficiency virus 1; Human viral diseases; Humans; Imidazoles; Imidazoles - pharmacokinetics; Imidazoles - pharmacology; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Male; Medical sciences; Middle Aged; Models, Biological; Pharmacodynamics; Pharmacokinetics; Pharmacology. Drug treatments; RNA; Statistical analysis; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Immunopathology; Pharmacokinetic pharmacodynamic relationship; Antiretroviral agent; Patient; AIDS; Chemokine receptor; CC chemokine; Immune deficiency; Infection; CCR5 chemokine receptor; Treatment; Viral disease; Antiviral; Antagonist
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.00713-10

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