Intracellular Metabolism and Persistence of the Anti-Human Immunodeficiency Virus Activity of 2′,3′-Didehydro-3′-Deoxy-4′-Ethynylthymidine, a Novel Thymidine Analog

• Published in: Antimicrobial Agents and Chemotherapy Vol. 51; no. 11; pp. 3870 - 3879
• Main Authors: PAINTSIL, Elijah, DUTSCHMAN, Ginger E, RONG HU, GRILL, Susan P, LAM, Wing, BABA, Masanori, TANAKA, Hiromichi, CHENG, Yung-Chi
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.11.2007; American Society for Microbiology (ASM)
• Subjects: Anti-HIV Agents - metabolism; Anti-HIV Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Biological and medical sciences; Cell Line; Dideoxynucleotides - metabolism; Dideoxynucleotides - pharmacology; Dose-Response Relationship, Drug; HeLa Cells; HIV; HIV - drug effects; HIV - growth & development; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Medical sciences; Pharmacology. Drug treatments; Phosphorylation; Reverse Transcriptase Inhibitors - metabolism; Reverse Transcriptase Inhibitors - pharmacology; Stavudine; Stavudine - analogs & derivatives; Stavudine - metabolism; Stavudine - pharmacology; Thymine Nucleotides - metabolism; Thymine Nucleotides - pharmacology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virus Replication - drug effects; Zidovudine - analogs & derivatives; Zidovudine - metabolism; Zidovudine - pharmacology; Immunopathology; Retroviridae; AIDS; Thymidine; Metabolism; Immune deficiency; Lentivirus; Biological activity; Infection; Virus; Persistence; Viral disease; Analog; Intracellular; Human immunodeficiency virus; Pharmacokinetics; Pyrimidine nucleoside
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.00692-07

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