Effect of Protein Binding on the Pharmacological Activity of Highly Bound Antibiotics

• Published in: Antimicrobial Agents and Chemotherapy Vol. 52; no. 11; pp. 3994 - 4000
• Main Authors: SCHMIDT, Stephan, ROCK, Katharina, SAHRE, Martina, BURKHARDT, Olaf, BRUNNER, Martin, LOBMEYER, Maximilian T, DERENDORF, Hartmut
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.11.2008; American Society for Microbiology (ASM)
• Subjects: Animals; Anti-Bacterial Agents; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; beta-Lactams - metabolism; beta-Lactams - pharmacology; Biological and medical sciences; Blood Proteins; Blood Proteins - metabolism; Cattle; Ceftriaxone - metabolism; Ceftriaxone - pharmacology; Drug Discovery; Escherichia coli; Escherichia coli - drug effects; Humans; In Vitro Techniques; Medical sciences; Models, Biological; Pharmacology; Pharmacology. Drug treatments; Protein Binding; Serum Albumin - metabolism; Serum Albumin, Bovine - metabolism; Streptococcus pneumoniae; Streptococcus pneumoniae - drug effects; β-Lactams; Escherichia coli; Free form; Ceftriaxone; Metabolism; Ertapenem; Activity metabolism relation; Bound form; Streptococcus pneumoniae; Streptococcaceae; Binding protein; Cephalosporin derivatives; Carbapenem derivatives; Antibiotic; Biological fixation; Sensitivity resistance; Bacteria; Micrococcales; Pharmacokinetics; Antibacterial agent; Enterobacteriaceae
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.00427-08

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