Antimalarial Activity of Phenylthiazolyl-Bearing Hydroxamate-Based Histone Deacetylase Inhibitors

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Published inAntimicrobial Agents and Chemotherapy Vol. 52; no. 10; pp. 3467 - 3477
Main Authors DOW, Geoffrey S, YUFENG CHEN, TRAN, Thanh N, KOZIKOWSKI, Alan P, ANDREWS, Katherine T, CARIDHA, Diana, GERENA, Lucia, GETTAYACAMIN, Montip, JOHNSON, Jacob, QIGUI LI, MELENDEZ, Victor, OBALDIA, Nicanor
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.10.2008
American Society for Microbiology (ASM)
Subjects
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials
Antimalarials - pharmacology
Antiparasitic agents
Aotidae
Aotus lemurinus lemurinus
Biological and medical sciences
Drug Resistance
Enzyme Inhibitors
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacokinetics
Enzyme Inhibitors - pharmacology
Experimental Therapeutics
Histone Deacetylase Inhibitors
Hydroxamic Acids - chemical synthesis
Hydroxamic Acids - pharmacokinetics
Hydroxamic Acids - pharmacology
In Vitro Techniques
Malaria - drug therapy
Malaria, Falciparum - drug therapy
Male
Medical sciences
Mice
Mice, Inbred ICR
Pharmacology. Drug treatments
Plasmodium
Plasmodium - drug effects
Plasmodium berghei - drug effects
Plasmodium falciparum
Plasmodium falciparum - drug effects
Structure-Activity Relationship
Thiazoles - chemical synthesis
Thiazoles - pharmacokinetics
Thiazoles - pharmacology
Antimalarial
Histone deacetylase inhibitor
Structure activity relation
Toxicity
Animal
Thiazole derivatives
Treatment efficiency
Hydroxamic acid
Parasiticide
In vitro
Biological activity
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Mailing address for G. S. Dow: Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Ave., Silver Spring, MD 20910. Phone: (301) 319-9009. Fax: (301) 319-9954. E-mail: Geoffrey.Dow@amedd.army.mil. Mailing address for A. Kozikowski: Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood, Chicago, IL 60612. Phone: (312) 996-7577. Fax: (312) 413-1701. E-mail: kozikowa@uic.edu
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.00439-08