Multiple-Dose Escalation Study of the Safety, Pharmacokinetics, and Biologic Activity of Oral AMD070, a Selective CXCR4 Receptor Inhibitor, in Human Subjects

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Published inAntimicrobial Agents and Chemotherapy Vol. 51; no. 7; pp. 2351 - 2358
Main Authors Stone, Nimalie D., Dunaway, Shelia B., Flexner, Charles, Tierney, Camlin, Calandra, Gary B., Becker, Stephen, Cao, Ying-Jun, Wiggins, Ilene P., Conley, Jeanne, MacFarland, Ron T., Park, Jeong-Gun, Lalama, Christina, Snyder, Sally, Kallungal, Beatrice, Klingman, Karin L., Hendrix, Craig W.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.07.2007
American Society for Microbiology (ASM)
Subjects
Administration, Oral
Adolescent
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Area Under Curve
Biological and medical sciences
Cohort Studies
Dose-Response Relationship, Drug
Fasting
Half-Life
Headache - chemically induced
Heterocyclic Compounds, 1-Ring
Heterocyclic Compounds, 1-Ring - administration & dosage
Heterocyclic Compounds, 1-Ring - adverse effects
Heterocyclic Compounds, 1-Ring - blood
Heterocyclic Compounds, 1-Ring - pharmacokinetics
Heterocyclic Compounds, 1-Ring - urine
Human immunodeficiency virus 1
Humans
Leukocytes - drug effects
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Receptors, CXCR4
Receptors, CXCR4 - antagonists & inhibitors
Time Factors
Multiple dose
Human
Increasing dose
Toxicity
Oral administration
Inhibitor
Pharmacokinetics
Biological activity
CXCR4 chemokine receptor
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Summary:ERRATUM ( vol. 51 , p. 3047 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Present address: Emory University School of Medicine, Division of Infectious Diseases, Woodruff Memorial Building 2101, 1639 Pierce Dr., Atlanta, GA 30322.
Corresponding author. Mailing address: Johns Hopkins University School of Medicine, Division of Clinical Pharmacology, Harvey 502, 600 N. Wolfe Street, Baltimore, MD 21287. Phone: (410) 955-9707. Fax: (410) 955-9708. E-mail: chendrix@jhmi.edu
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.00013-07