Antiparasitic Activities and Toxicities of Individual Enantiomers of the 8-Aminoquinoline 8-[(4-Amino-1-Methylbutyl)Amino]-6-Methoxy-4-Methyl-5-[3,4-Dichlorophenoxy]Quinoline Succinate

• Published in: Antimicrobial Agents and Chemotherapy Vol. 52; no. 6; pp. 2130 - 2137
• Main Authors: DHAMMIKA NANAYAKKARA, N. P, AGER, Arba L, BARTLETT, Marilyn S, YARDLEY, Vanessa, CROFT, Simon L, KHAN, Ikhlas A, MCCHESNEY, James D, WALKER, Larry A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.06.2008; American Society for Microbiology (ASM)
• Subjects: Aminoquinolines; Aminoquinolines - chemistry; Aminoquinolines - pharmacology; Aminoquinolines - therapeutic use; Aminoquinolines - toxicity; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antifungal Agents - toxicity; Antiprotozoal Agents; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - pharmacology; Antiprotozoal Agents - toxicity; Biological and medical sciences; Dogs; Female; Hemolysis; Humans; Leishmania donovani; Leishmania donovani - drug effects; Leishmaniasis, Visceral - drug therapy; Leishmaniasis, Visceral - parasitology; Malaria - drug therapy; Malaria - parasitology; Male; Medical sciences; Methemoglobinemia - etiology; Mice; Mice, Inbred BALB C; Pharmacology. Drug treatments; Plasmodium berghei; Plasmodium berghei - drug effects; Pneumocystis carinii; Pneumocystis carinii - drug effects; Pneumonia, Pneumocystis - drug therapy; Pneumonia, Pneumocystis - microbiology; Stereoisomerism; Structure-Activity Relationship; Susceptibility; Human; Quinoline; Parasiticide; Toxicity; Enantiomer; Biological activity
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.00645-07

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