Proinflammatory and Oxidative Stress Markers in Patients with Periodontal Disease

• Published in: Mediators of Inflammation Vol. 2007; no. 1; pp. 1 - 5
• Main Authors: BORGES, Ivan, ADDISON MACHADO MOREIRA, Emilia, WILHEM, Danilo, BITTENCOURT DE OLIVEIRA, Tiago, BARRETO SPIRELLE DA SILVA, Marcelo, FRÖDE, Tania Silvia
• Format: Journal Article
• Language: English
• Published: Sylvania, OH Hindawi Limiteds 01.01.2007; Hindawi; Hindawi Limited; Hindawi Publishing Corporation; Wiley
• Subjects: Antioxidants - metabolism; Biological and medical sciences; Biomarkers - metabolism; Case-Control Studies; Clinical Study; Development and progression; Evaluation; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; General aspects; Gingiva - metabolism; Glutathione - metabolism; Gums; Health aspects; Humans; Immune response; Inflammation; Inflammation - metabolism; Inflammation - pathology; Male; Medical sciences; Middle Aged; Otorhinolaryngology. Stomatology; Oxidative Stress; Periodontal disease; Periodontal Diseases - metabolism; Peroxidase - metabolism; Physiological aspects; Properties; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Brazil; Human; Biological marker; Oxidative stress; Periodontal disease; Inflammation; Stomatology
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2007/45794

To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis. Eighteen subjects were divided in two groups: experimental (age 52.9+/-5.0) and control (age 51.1+/-9.6). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), and myeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Student t test and P<.05. Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group (P<.05). The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.