Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma

• Published in: Journal of Oncology Vol. 2016; no. 2016; pp. 46 - 53
• Main Authors: Lauris, José Roberto Pereira, Kowalski, Luiz Paulo, Nonogaki, Suely, García-García, Abel, Pérez-Sayáns, Mario, Suárez-Peñaranda, José-Manuel, Assao, Agnes, Lauand, Gustavo Amaral, Bravo-Calderón, Diego Maurício, Oliveira, Denise Tostes, Marana, Aparecido Nilceu
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2016; Hindawi Publishing Corporation; John Wiley & Sons, Inc
• Subjects: Adrenergic receptors; Analysis; Angiogenesis; Antibodies; Antigens; Beta adrenoceptors; Care and treatment; Catecholamines; Development and progression; Diagnosis; Gene expression; Genetic aspects; Health aspects; Investigations; Kinases; Ligands; Lymphatic system; Metastasis; Oral cancer; Otolaryngology; Physiological aspects; Proteins; Radiation therapy; Software; Squamous cell carcinoma; Statistical analysis; Surgery; Tumors; Brazil; St Louis Missouri; United States > US; Germany
• ISSN: 1687-8450; 1687-8450
• DOI: 10.1155/2016/3531274

Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis. Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (β2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association with β2-AR expression was verified by the chi-square test or Fischer’s exact test. To verify the correlation of β2-AR expression in tumor-free surgical margins and at the invasive front of OSCCs, Pearson’s correlation coefficient test was applied. Results. The expression of β2-AR presented a statistically significant correlation between the tumor-free surgical margins and the invasive front of OSCC (r=0.383; p=0.002). The immunohistochemical distribution of β2-AR at the invasive front of OSCC was also statistically significant associated with alcohol (p=0.038), simultaneous alcohol and tobacco consumption (p=0.010), and T stage (p=0.014). Conclusions. The correlation of β2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive.