Nanoparticle-Stabilized Capsules for the Treatment of Bacterial Biofilms

• Published in: ACS nano Vol. 9; no. 8; pp. 7775 - 7782
• Main Authors: Duncan, Bradley, Li, Xiaoning, Landis, Ryan F, Kim, Sung Tae, Gupta, Akash, Wang, Li-Sheng, Ramanathan, Rajesh, Tang, Rui, Boerth, Jeffrey A, Rotello, Vincent M
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.08.2015
• Subjects: Acrolein - analogs & derivatives; Acrolein - chemistry; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antiinfectives and antibacterials; Bacteria; Biofilms; Biofilms - drug effects; Biofilms - growth & development; Biological Transport; Capsules; Cell Proliferation - drug effects; Cinnamaldehyde; Coculture Techniques; Drug Carriers; Drug Compounding; Emulsions; Enterobacter cloacae - drug effects; Enterobacter cloacae - physiology; Escherichia coli - drug effects; Escherichia coli - physiology; High resistance; Mentha piperita; Methicillin-Resistant Staphylococcus aureus - drug effects; Methicillin-Resistant Staphylococcus aureus - physiology; Mice; Microbial Sensitivity Tests; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Nanostructure; NIH 3T3 Cells; Photoelectron Spectroscopy; Plant Oils - chemistry; Plant Oils - pharmacology; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - physiology; Self assembly; self-assembly; phytochemicals; Pickering emulsion; silica nanoparticles; biofilm
• ISSN: 1936-0851; 1936-086X
• DOI: 10.1021/acsnano.5b01696

Bacterial biofilms are widely associated with persistent infections. High resistance to conventional antibiotics and prevalent virulence makes eliminating these bacterial communities challenging therapeutic targets. We describe here the fabrication of a nanoparticle-stabilized capsule with a multicomponent core for the treatment of biofilms. The peppermint oil and cinnamaldehyde combination that comprises the core of the capsules act as potent antimicrobial agents. An in situ reaction at the oil/water interface between the nanoparticles and cinnamaldehyde structurally augments the capsules to efficiently deliver the essential oil payloads, effectively eradicating biofilms of clinically isolated pathogenic bacteria strains. In contrast to their antimicrobial action, the capsules selectively promoted fibroblast proliferation in a mixed bacteria/mammalian cell system making them promising for wound healing applications.