Contaminated handwashing sinks as the source of a clonal outbreak of KPC-2-producing Klebsiella oxytoca on a hematology ward

We investigated sinks as possible sources of a prolonged Klebsiella pneumonia carbapenemase (KPC)-producing Klebsiella oxytoca outbreak. Seven carbapenem-resistant K. oxytoca isolates were identified in sink drains in 4 patient rooms and in the medication room. Investigations for resistance genes an...

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Published inAntimicrobial agents and chemotherapy Vol. 59; no. 1; pp. 714 - 716
Main Authors Leitner, Eva, Zarfel, Gernot, Luxner, Josefa, Herzog, Kathrin, Pekard-Amenitsch, Shiva, Hoenigl, Martin, Valentin, Thomas, Feierl, Gebhard, Grisold, Andrea J, Högenauer, Christoph, Sill, Heinz, Krause, Robert, Zollner-Schwetz, Ines
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.01.2015
Subjects
beta-Lactamases
Cross Infection
Cross Infection - epidemiology
Cross Infection - etiology
Cross Infection - microbiology
Disease Outbreaks
Equipment Contamination
Hand Disinfection
Hematology
Hospital Departments
Humans
Klebsiella
Klebsiella Infections
Klebsiella Infections - epidemiology
Klebsiella Infections - etiology
Klebsiella Infections - microbiology
Klebsiella oxytoca
Klebsiella oxytoca - enzymology
Mechanisms of Resistance
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Summary:We investigated sinks as possible sources of a prolonged Klebsiella pneumonia carbapenemase (KPC)-producing Klebsiella oxytoca outbreak. Seven carbapenem-resistant K. oxytoca isolates were identified in sink drains in 4 patient rooms and in the medication room. Investigations for resistance genes and genetic relatedness of patient and environmental isolates revealed that all the isolates harbored the blaKPC-2 and blaTEM-1 genes and were genetically indistinguishable. We describe here a clonal outbreak caused by KPC-2-producing K. oxytoca, and handwashing sinks were a possible reservoir.
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Citation Leitner E, Zarfel G, Luxner J, Herzog K, Pekard-Amenitsch S, Hoenigl M, Valentin T, Feierl G, Grisold AJ, Högenauer C, Sill H, Krause R, Zollner-Schwetz I. 2015. Contaminated handwashing sinks as the source of a clonal outbreak of KPC-2-producing Klebsiella oxytoca on a hematology ward. Antimicrob Agents Chemother 59:714–716. doi:10.1128/AAC.04306-14.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.04306-14