Double-Stranded RNA Sensors and Modulators in Innate Immunity

Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune defense in many organisms. We here discuss several families of dsRNA-binding proteins involved in mammalian antiviral innate immunity. These include RIG-I-like receptors, protein kinase R, oligoadenylate synthases, ad...

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Bibliographic Details
Published inAnnual review of immunology Vol. 37; no. 1; pp. 349 - 375
Main Author Hur, Sun
Format Journal Article
LanguageEnglish
Published United States Annual Reviews 26.04.2019
Subjects
dsRNA
dsRNA-dependent adenosine deaminase
oligoadenylate synthase
protein kinase R
RIG-I-like receptor
RNA interference
dsRNA
oligoadenylate synthase
RNA interference
dsRNA-dependent adenosine deaminase
RIG-I-like receptor
protein kinase R
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Summary:Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune defense in many organisms. We here discuss several families of dsRNA-binding proteins involved in mammalian antiviral innate immunity. These include RIG-I-like receptors, protein kinase R, oligoadenylate synthases, adenosine deaminases acting on RNA, RNA interference systems, and other proteins containing dsRNA-binding domains and helicase domains. Studies suggest that their functions are highly interdependent and that their interdependence could offer keys to understanding the complex regulatory mechanisms for cellular dsRNA homeostasis and antiviral immunity. This review aims to highlight their interconnectivity, as well as their commonalities and differences in their dsRNA recognition mechanisms.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev-immunol-042718-041356