The Three-Dimensional Organization of Mammalian Genomes

Animal development depends on not only the linear genome sequence that embeds millions of cis -regulatory elements, but also the three-dimensional (3D) chromatin architecture that orchestrates the interplay between cis -regulatory elements and their target genes. Compared to our knowledge of the cis...

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Bibliographic Details
Published inAnnual review of cell and developmental biology Vol. 33; no. 1; pp. 265 - 289
Main Authors Yu, Miao, Ren, Bing
Format Journal Article
LanguageEnglish
Published United States Annual Reviews 06.10.2017
Subjects
3D chromatin organization
chromosome conformation capture
gene regulation
TAD
topologically associating domain
chromosome conformation capture
3D chromatin organization
gene regulation
topologically associating domain
TAD
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Summary:Animal development depends on not only the linear genome sequence that embeds millions of cis -regulatory elements, but also the three-dimensional (3D) chromatin architecture that orchestrates the interplay between cis -regulatory elements and their target genes. Compared to our knowledge of the cis -regulatory sequences, the understanding of the 3D genome organization in human and other eukaryotes is still limited. Recent advances in technologies to map the 3D genome architecture have greatly accelerated the pace of discovery. Here, we review emerging concepts of chromatin organization in mammalian cells, discuss the dynamics of chromatin conformation during development, and highlight important roles for chromatin organization in cancer and other human diseases.
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ISSN:1081-0706
1530-8995
DOI:10.1146/annurev-cellbio-100616-060531