Accuracy of [^(18)Fluorine]-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography-Computed Tomography Response Assessment Following (Chemo)radiotherapy for Locally Advanced Laryngeal/Hypopharyngeal Carcinoma

Introduction: The accuracy of response assessment positron emission tomography (PET)-computed tomography (CT) following radiotherapy with or without chemotherapy for laryngeal/hypopharyngeal squamous cell carcinoma is uncertain. Methods: In all, 35 patients with laryngeal or hypopharyngeal squamous...

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Published inClinical Medicine Insights. Oncology Vol. 11; p. 1179554917713005
Main Authors Slevin, Finbar, Ermiş, Ekin, Vaidyanathan, Sriram, Sen, Mehmet, Scarsbrook, Andrew F, Prestwich, Robin Jd
Format Journal Article
LanguageEnglish
Published London, England Libertas Academica 2017
SAGE Publications
Sage Publications Ltd
Subjects
Accuracy
Authorship
Dissection
Glucose
Head & neck cancer
Larynx
Lymphatic system
Medical imaging
Metabolism
NMR
Nuclear magnetic resonance
Original Research
Peer review
Radiation therapy
Studies
Surgery
Surveillance
Throat cancer
Tomography
radiotherapy
PET-CT
Larynx
hypopharynx
cancer
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Summary:Introduction: The accuracy of response assessment positron emission tomography (PET)-computed tomography (CT) following radiotherapy with or without chemotherapy for laryngeal/hypopharyngeal squamous cell carcinoma is uncertain. Methods: In all, 35 patients with laryngeal or hypopharyngeal squamous cell carcinoma who were treated between 2009 and 2014 with (chemo)radiotherapy were identified. The accuracy of response assessment PET-CT was made by correlation with clinical follow-up and pathological findings. Results: Of the 35 patients, 20 (57%) had an overall complete metabolic response. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for response assessment [18Fluorine]-fluoro-2-deoxy-D-glucose (FDG) PET-CT for primary and nodal sites, respectively, were 100%, 73%, 46%, and 100% and 83%, 95%, 83%, and 95%. Conclusions: Response assessment FDG PET-CT following (chemo)radiotherapy for laryngeal and hypopharyngeal carcinomas has a high NPV for both primary site and lymph nodes and can be used to guide treatment decisions. The PPV of residual FDG uptake at the primary tumour site is limited and requires examination and biopsy confirmation.
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ISSN:1179-5549
1179-5549
DOI:10.1177/1179554917713005