Fungal Biofilm Resistance

Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required. This places a large financial burden on health...

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Bibliographic Details
Published inInternational Journal of Microbiology Vol. 2012; no. 2012; pp. 279 - 292
Main Authors Ramage, Gordon, Rajendran, Ranjith, Sherry, Leighann, Williams, Craig
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 2012
Hindawi Puplishing Corporation
Hindawi Publishing Corporation
Wiley
Subjects
Review
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Summary:Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required. This places a large financial burden on health care providers. This paper aims to illustrate the importance of fungal biofilms, particularly Candida albicans, and discusses some of the key fungal biofilm resistance mechanisms that include, extracellular matrix (ECM), efflux pump activity, persisters, cell density, overexpression of drug targets, stress responses, and the general physiology of the cell. The paper demonstrates the multifaceted nature of fungal biofilm resistance, which encompasses some of the newest data and ideas in the field.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Nir Osherov
ISSN:1687-918X
1687-9198
DOI:10.1155/2012/528521