The Role of Molecular Microtubule Motors and the Microtubule Cytoskeleton in Stress Granule Dynamics

Stress granules (SGs) are cytoplasmic foci that appear in cells exposed to stress-induced translational inhibition. SGs function as a triage center, where mRNAs are sorted for storage, degradation, and translation reinitiation. The underlying mechanisms of SGs dynamics are still being characterized,...

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Bibliographic Details
Published inInternational Journal of Cell Biology Vol. 2011; no. 2011; pp. 233 - 241
Main Authors Bartoli, Kristen M., Bishop, Darryl L., Saunders, William S.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Limiteds 2011
Hindawi Puplishing Corporation
Hindawi Publishing Corporation
Hindawi Limited
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Review
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Summary:Stress granules (SGs) are cytoplasmic foci that appear in cells exposed to stress-induced translational inhibition. SGs function as a triage center, where mRNAs are sorted for storage, degradation, and translation reinitiation. The underlying mechanisms of SGs dynamics are still being characterized, although many key players have been identified. The main components of SGs are stalled 48S preinitiation complexes. To date, many other proteins have also been found to localize in SGs and are hypothesized to function in SG dynamics. Most recently, the microtubule cytoskeleton and associated motor proteins have been demonstrated to function in SG dynamics. In this paper, we will discuss current literature examining the function of microtubules and the molecular microtubule motors in SG assembly, coalescence, movement, composition, organization, and disassembly.
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Academic Editor: Timothy J. Yen
ISSN:1687-8876
1687-8884
DOI:10.1155/2011/939848