Discovery and Characterization of Vicriviroc (SCH 417690), a CCR5 Antagonist with Potent Activity against Human Immunodeficiency Virus Type 1

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Published inAntimicrobial Agents and Chemotherapy Vol. 49; no. 12; pp. 4911 - 4919
Main Authors STRIZKI, Julie M, TREMBLAY, Cecile, TAGAT, Jayaram R, COX, Kathleen, PRIESTLEY, Tony, SOROTA, Steve, WEI HUANG, HIRSCH, Martin, REYES, Gregory R, BAROUDY, Bahige M, XU, Serena, WOJCIK, Lisa, WAGNER, Nicole, GONSIOREK, Waldemar, HIPKIN, R. William, CHOU, Chuan-Chu, PUGLIESE-SIVO, Catherine, YUSHI XIAO
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.12.2005
Subjects
Anti-HIV Agents
Anti-HIV Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Biological and medical sciences
CCR5 Receptor Antagonists
HIV-1
HIV-1 - drug effects
Human immunodeficiency virus
Human immunodeficiency virus 1
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Leukocytes, Mononuclear
Medical sciences
Pharmacology. Drug treatments
Piperazines
Piperazines - pharmacology
Pyrimidines
Pyrimidines - pharmacology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Immunopathology
HIV-1 virus
Retroviridae
AIDS
Chemokine receptor
CC chemokine
Discoveries
Immune deficiency
Lentivirus
Biological activity
Infection
Virus
CCR5 chemokine receptor
Viral disease
Human immunodeficiency virus
Antagonist
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Mailing address: Schering-Plough Research Institute, Antiviral Therapy, 2015 Galloping Hill Road, K15, E405C/4945, Kenilworth, NJ 07033. Phone: (908) 740-4731. Fax: (908) 740-3032. E-mail: Julie.strizki@spcorp.com.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.49.12.4911-4919.2005