Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro

• Published in: Antimicrobial Agents and Chemotherapy Vol. 49; no. 10; pp. 4305 - 4314
• Main Authors: Mo, Hongmei, Lu, Liangjun, Pilot-Matias, Tami, Pithawalla, Ron, Mondal, Rubina, Masse, Sherie, Dekhtyar, Tatyana, Ng, Teresa, Koev, Gennadiy, Stoll, Vincent, Stewart, Kent D, Pratt, John, Donner, Pam, Rockway, Todd, Maring, Clarence, Molla, Akhteruzzaman
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.10.2005
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Binding Sites; Biological and medical sciences; Cell Line; Drug Resistance, Viral; Drug Resistance, Viral - genetics; Enzyme Inhibitors; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Hepacivirus; Hepacivirus - drug effects; Hepacivirus - enzymology; Hepacivirus - genetics; Human viral diseases; Infectious diseases; Medical sciences; Models, Molecular; Molecular Structure; Mutation; Pharmacology. Drug treatments; Protein Binding; Replicon - genetics; RNA Replicase; RNA Replicase - antagonists & inhibitors; RNA, Viral - genetics; Serine Proteinase Inhibitors; Serine Proteinase Inhibitors - chemistry; Serine Proteinase Inhibitors - pharmacology; Viral diseases; Viral hepatitis; Hepatitis A virus; Picornaviridae; Hepatic disease; Viral hepatitis A; Antiviral; Genetics; Drug combination; Serine endopeptidases; Enzyme; Transferases; In vitro; RNA-directed RNA polymerase; Hepatovirus; Infection; Virus; Resistance; Peptidases; Nucleotidyltransferases; Viral disease; Digestive diseases; Hydrolases; Mutation; Flaviviridae; Hepatitis C virus; Hepacivirus; Protease inhibitor
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.49.10.4305-4314.2005

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