Importance of Position 170 in the Inhibition of GES-Type β-Lactamases by Clavulanic Acid

• Published in: Antimicrobial Agents and Chemotherapy Vol. 55; no. 4; pp. 1556 - 1562
• Main Authors: FRASE, Hilary, TOTH, Marta, CHAMPION, Matthew M, ANTUNES, Nuno T, VAKULENKO, Sergei B
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.04.2011; American Society for Microbiology (ASM)
• Subjects: Aldehydes; Amino acid substitution; Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Asparagine; Asparagine - genetics; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactamases - genetics; beta-Lactamases - metabolism; Biological and medical sciences; carbapenemase; Carbapenems; Cephalosporins; Chromatography, Liquid; Clavulanic Acid; Clavulanic Acid - pharmacology; Enzyme Inhibitors; Enzyme Inhibitors - pharmacology; Enzymes; Glycine; Glycine - genetics; Infection; Mechanisms of Resistance; Medical sciences; Microbial Sensitivity Tests; Penicillin; Pharmacology. Drug treatments; Serine; Serine - genetics; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Enzyme; Clavulanic acid; Position; Enzyme inhibitor; Hydrolases; Inhibition; β-Lactamase; Antibacterial agent
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.01292-10

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