Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora

Five new [daphneodorins D–H (1, 5, and 10–12)] and seven known daphnane diterpenoids (2–4 and 6–9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV ac...

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Published inJournal of natural products (Washington, D.C.) Vol. 83; no. 11; pp. 3270 - 3277
Main Authors Otsuki, Kouharu, Li, Wei, Miura, Kasumi, Asada, Yoshihisa, Huang, Li, Chen, Chin-Ho, Lee, Kuo-Hsiung, Koike, Kazuo
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 25.11.2020
Amer Chemical Soc
Subjects
antiretroviral properties
Chemistry, Medicinal
Daphne odora
diterpenoids
HIV infections
Life Sciences & Biomedicine
ortho esters
Pharmacology & Pharmacy
Plant Sciences
Science & Technology
spectral analysis
POTENT INHIBITORY-ACTIVITY
ACID
ESTERS
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Abstract Five new [daphneodorins D–H (1, 5, and 10–12)] and seven known daphnane diterpenoids (2–4 and 6–9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1–9) showed potent anti-HIV activity with EC50 values of 1.5–7.7 nM.
AbstractList Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC50 values of 1.5-7.7 nM.Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC50 values of 1.5-7.7 nM.
Five new [daphneodorins D–H (1, 5, and 10–12)] and seven known daphnane diterpenoids (2–4 and 6–9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1–9) showed potent anti-HIV activity with EC₅₀ values of 1.5–7.7 nM.
Five new [daphneodorins D–H ( 1 , 5 , and 10 – 12 )] and seven known daphnane diterpenoids ( 2 – 4 and 6 – 9 ) were isolated from Daphne odora . The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters ( 1 – 9 ) showed potent anti-HIV activity with EC 50 values of 1.5–7.7 nM.
Five new [daphneodorins D–H (1, 5, and 10–12)] and seven known daphnane diterpenoids (2–4 and 6–9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1–9) showed potent anti-HIV activity with EC50 values of 1.5–7.7 nM.
Five new [daphneodorins D-H ( , , and - )] and seven known daphnane diterpenoids ( - and - ) were isolated from . The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters ( - ) showed potent anti-HIV activity with EC values of 1.5-7.7 nM.
Author Miura, Kasumi
Chen, Chin-Ho
Huang, Li
Asada, Yoshihisa
Lee, Kuo-Hsiung
Li, Wei
Koike, Kazuo
Otsuki, Kouharu
AuthorAffiliation Faculty of Pharmaceutical Sciences
University of North Carolina
Toho University
Natural Products Research Laboratories, UNC Eshelman School of Pharmacy
Surgical Science, Department of Surgery
Chinese Medicine Research and Development Center
China Medical University and Hospital
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Snippet Five new [daphneodorins D–H (1, 5, and 10–12)] and seven known daphnane diterpenoids (2–4 and 6–9) were isolated from Daphne odora. The structures of the new...
Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new...
Five new [daphneodorins D-H ( , , and - )] and seven known daphnane diterpenoids ( - and - ) were isolated from . The structures of the new compounds were...
Five new [daphneodorins D–H ( 1 , 5 , and 10 – 12 )] and seven known daphnane diterpenoids ( 2 – 4 and 6 – 9 ) were isolated from Daphne odora . The structures...
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SubjectTerms antiretroviral properties
Chemistry, Medicinal
Daphne odora
diterpenoids
HIV infections
Life Sciences & Biomedicine
ortho esters
Pharmacology & Pharmacy
Plant Sciences
Science & Technology
spectral analysis
Title Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora
URI http://dx.doi.org/10.1021/acs.jnatprod.0c00540
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000595546200007
https://www.ncbi.nlm.nih.gov/pubmed/32997496
https://www.proquest.com/docview/2447836296
https://www.proquest.com/docview/2552004121
https://pubmed.ncbi.nlm.nih.gov/PMC8176625
Volume 83
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