Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora

Five new [daphneodorins D–H (1, 5, and 10–12)] and seven known daphnane diterpenoids (2–4 and 6–9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV ac...

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Published inJournal of natural products (Washington, D.C.) Vol. 83; no. 11; pp. 3270 - 3277
Main Authors Otsuki, Kouharu, Li, Wei, Miura, Kasumi, Asada, Yoshihisa, Huang, Li, Chen, Chin-Ho, Lee, Kuo-Hsiung, Koike, Kazuo
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 25.11.2020
Amer Chemical Soc
Subjects
antiretroviral properties
Chemistry, Medicinal
Daphne odora
diterpenoids
HIV infections
Life Sciences & Biomedicine
ortho esters
Pharmacology & Pharmacy
Plant Sciences
Science & Technology
spectral analysis
POTENT INHIBITORY-ACTIVITY
ACID
ESTERS
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Summary:Five new [daphneodorins D–H (1, 5, and 10–12)] and seven known daphnane diterpenoids (2–4 and 6–9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1–9) showed potent anti-HIV activity with EC50 values of 1.5–7.7 nM.
Bibliography:KAKEN
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0163-3864
1520-6025
1520-6025
DOI:10.1021/acs.jnatprod.0c00540