Pulmonary Edema in COVID19A Neural Hypothesis
In COVID-19, lung manifestations present as a slowly evolving pneumonia with insidious early onset interstitial pulmonary edema that undergoes acute exacerbation in the late stages and microvascular thrombosis. Currently, these manifestations are considered to be only consequences of pulmonary SARS-...
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Published in | ACS Chemical Neuroscience Vol. 11; no. 14; pp. 2048 - 2050 |
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Main Authors | , |
Format | Journal Article Web Resource |
Language | English |
Published |
United States
American Chemical Society
15.07.2020
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Subjects | |
Online Access | Get full text |
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Summary: | In COVID-19, lung manifestations present as a slowly evolving pneumonia with insidious early onset interstitial pulmonary edema that undergoes acute exacerbation in the late stages and microvascular thrombosis. Currently, these manifestations are considered to be only consequences of pulmonary SARS-CoV-2 virus infection. We are proposing a new hypothesis that neurogenic insult may also play a major role in the pathogenesis of these manifestations. SARS-CoV-2 mediated inflammation of the nucleus tractus solitarius (NTS) may play a role in the acute exacerbation of pulmonary edema and microvascular clotting in COVID-19 patients. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1948-7193 1948-7193 |
DOI: | 10.1021/acschemneuro.0c00370 |