Mechanism of Action of a Novel Series of Naphthyridine-Type Ribosome Inhibitors: Enhancement of tRNA Footprinting at the Decoding Site of 16S rRNA

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Published inAntimicrobial Agents and Chemotherapy Vol. 49; no. 5; pp. 1890 - 1897
Main Authors Shen, Linus L, Black-Schaefer, Candace, Cai, Yingna, Dandliker, Peter J, Beutel, Bruce A
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.05.2005
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Autoradiography
Bacterial Proteins - biosynthesis
Bacterial Proteins - genetics
Biological and medical sciences
DNA Primers
Escherichia coli
Gene Expression Regulation, Bacterial
Mechanisms of Action: Physiological Effects
Medical sciences
Models, Molecular
Naphthyridines
Naphthyridines - pharmacology
Pharmacology. Drug treatments
Protein Biosynthesis
Protein Footprinting
Radioligand Assay
Ribosomes
Ribosomes - drug effects
RNA, Ribosomal, 16S
RNA, Ribosomal, 16S - drug effects
RNA, Transfer
RNA, Transfer - biosynthesis
RNA, Transfer - genetics
Streptococcus pneumoniae - drug effects
Streptococcus pneumoniae - genetics
16S-RNA
Ribosome
tRNA
Mechanism of action
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Mailing address: Abbott Laboratories, Department R47R, Bldg. AP10, 100 Abbott Park Rd., Abbott Park, IL 60064-6099. Phone: (847) 937-5983. Fax: (847) 938-1674. E-mail: linus.l.shen@abbott.com.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.49.5.1890-1897.2005