Spread of NDM-1-Producing Enterobacteriaceae in a Neonatal Intensive Care Unit in Istanbul, Turkey

• Published in: Antimicrobial agents and chemotherapy Vol. 58; no. 5; pp. 2929 - 2933
• Main Authors: POIREL, Laurent, YILMAZ, Mesut, ISTANBULLU, Ayse, ARSLAN, Ferhat, MERT, Ali, BERNABEU, Sandrine, NORDMANN, Patrice
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.05.2014
• Subjects: Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; beta-Lactamases; beta-Lactamases - genetics; Biological and medical sciences; Enterobacter cloacae; Enterobacteriaceae; Enterobacteriaceae - enzymology; Enterobacteriaceae - genetics; Escherichia coli; Escherichia coli - enzymology; Female; Human bacterial diseases; Humans; Infant, Newborn; Infectious diseases; Intensive Care Units; Klebsiella pneumoniae; Klebsiella pneumoniae - enzymology; Male; Mechanisms of Resistance; Medical sciences; Microbial Sensitivity Tests; Turkey; Asia; Turkey; Human; Enterobacter cloacae; Newborn; Carbapenemase producing; Bacteria; Hospital; Clinical isolate; Intensive care unit; Enterobacteriaceae
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.02047-13

Twenty-two consecutive carbapenem-resistant enterobacterial isolates were recovered from patients hospitalized between January and April 2013 in different units at a university hospital in Istanbul, Turkey. These were Klebsiella pneumoniae isolates producing the carbapenemases OXA-48, NDM-1, and KPC-2, Enterobacter cloacae isolates producing NDM-1, and Escherichia coli isolates producing OXA-48. Most of the OXA-48-producing K. pneumoniae and all the NDM-1-producing E. cloacae were clonally related. The NDM-1-producing E. cloacae isolates recovered from a single neonatal intensive care unit corresponded to a single cluster, highlighting the spread of that clone in that setting.