The Antimalarial Potential of 4-Quinolinecarbinolamines May Be Limited due to Neurotoxicity and Cross-Resistance in Mefloquine-Resistant Plasmodium falciparum Strains

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Published inAntimicrobial Agents and Chemotherapy Vol. 48; no. 7; pp. 2624 - 2632
Main Authors DOW, Geoffrey S, KOENIG, Michael L, WOLF, Lesley, GERENA, Lucia, LOPEZ-SANCHEZ, Miriam, HUDSON, Thomas H, BHATTACHARJEE, Apurba K
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.07.2004
Subjects
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials
Antimalarials - pharmacology
Antimalarials - toxicity
Biological and medical sciences
Calcium - metabolism
Cells, Cultured
Drug Resistance
Homeostasis - drug effects
Mechanisms of Action: Physiological Effects
Medical sciences
Mefloquine
Mefloquine - analogs & derivatives
Mefloquine - pharmacology
Mefloquine - toxicity
Microscopy, Confocal
Models, Molecular
Nervous System Diseases
Nervous System Diseases - chemically induced
Nervous System Diseases - pathology
Neurons - drug effects
Neurons - metabolism
Pharmacology. Drug treatments
Phenanthrenes - pharmacology
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - ultrastructure
Predictive Value of Tests
Quantitative Structure-Activity Relationship
Rats
Protozoa
Antimalarial
Plasmodium falciparum
Apicomplexa
Neurotoxicity
Mefloquine
Toxicity
Parasiticide
Cross resistance
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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content type line 23
Corresponding author. Mailing address: Parasitology Department, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Ave., Silver Spring, MD 20910. Phone: (301) 319-9009. Fax: (301) 319-9954. E-mail: geoffrey.dow@na.amedd.army.mil.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.48.7.2624-2632.2004