CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of the eukaryotic cell division cycle and have also been implicated in the control of gene transcription and other processes. Cdk activity is governed by a complex network of regulatory subunits and phosphorylation events...

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Bibliographic Details
Published inAnnual review of cell and developmental biology Vol. 13; no. 1; pp. 261 - 291
Main Author Morgan, David O
Format Journal Article
LanguageEnglish
Published Palo Alto, CA 94303-0139 Annual Reviews 01.01.1997
4139 El Camino Way, P.O. Box 10139 Annual Reviews, Inc
USA
Subjects
Animals
cell cycle
Cell Cycle - physiology
cyclin
Cyclin-Dependent Kinases - chemistry
Cyclin-Dependent Kinases - physiology
Cyclins - chemistry
Cyclins - metabolism
Enzyme Activation
Humans
kinase structure
Molecular Structure
protein kinase
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Summary:Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of the eukaryotic cell division cycle and have also been implicated in the control of gene transcription and other processes. Cdk activity is governed by a complex network of regulatory subunits and phosphorylation events whose precise effects on Cdk conformation have been revealed by recent crystallographic studies. In the cell, these regulatory mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell division.
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ISSN:1081-0706
1530-8995
DOI:10.1146/annurev.cellbio.13.1.261