B cell signaling and fate decision

Antigen receptors on the surface of B lymphocytes trigger adaptive immune responses after encountering their cognate antigens but also control a series of antigen-independent checkpoints during B cell development. These physiological processes are regulated by the expression and function of cell sur...

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Bibliographic Details
Published inAnnual review of immunology Vol. 28; p. 21
Main Authors Kurosaki, Tomohiro, Shinohara, Hisaaki, Baba, Yoshihiro
Format Journal Article
LanguageEnglish
Published United States 01.01.2010
Subjects
Adaptive Immunity
Animals
B-Lymphocytes - cytology
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Cell Lineage
Humans
MicroRNAs - genetics
Receptors, Antigen, B-Cell - immunology
Receptors, Antigen, B-Cell - metabolism
Signal Transduction
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Summary:Antigen receptors on the surface of B lymphocytes trigger adaptive immune responses after encountering their cognate antigens but also control a series of antigen-independent checkpoints during B cell development. These physiological processes are regulated by the expression and function of cell surface receptors, intracellular signaling molecules, and transcription factors. The function of these proteins can be altered by a dynamic array of post-translational modifications, using two interconnected mechanisms. These modifications can directly induce an altered conformational state in the protein target of the modification itself. In addition, they can create new binding sites for other protein partners, thereby contributing to where and when such multiple protein assemblies are activated within cells. As a new type of post-transcriptional regulator, microRNAs have emerged to influence the development and function of B cells by affecting the expression of target mRNAs.
ISSN:1545-3278
DOI:10.1146/annurev.immunol.021908.132541