Phase I and II Study of the Safety, Virologic Effect, and Pharmacokinetics/Pharmacodynamics of Single-Dose 3-O-(3′,3′-Dimethylsuccinyl)Betulinic Acid (Bevirimat) against Human Immunodeficiency Virus Infection

• Published in: Antimicrobial Agents and Chemotherapy Vol. 51; no. 10; pp. 3574 - 3581
• Main Authors: Smith, Patrick F., Ogundele, Abayomi, Forrest, Alan, Wilton, John, Salzwedel, Karl, Doto, Judy, Allaway, Graham P., Martin, David E.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.10.2007
• Subjects: Adult; Algorithms; Anti-HIV Agents; Anti-HIV Agents - adverse effects; Anti-HIV Agents - pharmacokinetics; Anti-HIV Agents - therapeutic use; Bayes Theorem; Calibration; CD4 Lymphocyte Count; Clinical Therapeutics; Double-Blind Method; Drug Resistance, Viral; HIV Infections; HIV Infections - drug therapy; HIV-1; HIV-1 - genetics; Human immunodeficiency virus; Humans; Male; Models, Statistical; RNA, Viral - blood; Succinates; Succinates - adverse effects; Succinates - pharmacokinetics; Succinates - therapeutic use; Triterpenes; Triterpenes - adverse effects; Triterpenes - pharmacokinetics; Triterpenes - therapeutic use; Viral Load; Virus Replication - drug effects
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.00152-07

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