Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

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Published inAntimicrobial Agents and Chemotherapy Vol. 56; no. 8; pp. 4365 - 4374
Main Authors CHRIST, Frauke, SHAW, Stephen, PICKFORD, Chris, DEMEULEMEESTER, Jonas, DESIMMIE, Belete A, MARCHAND, Arnaud, BUTLER, Scott, SMETS, Wim, CHALTIN, Patrick, WESTBY, Mike, DEBYSER, Zeger
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.08.2012
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Binding Sites - drug effects
Biological and medical sciences
Catalytic Domain - drug effects
Cell Line
HIV Integrase
HIV Integrase - chemistry
HIV Integrase - metabolism
HIV Integrase Inhibitors
HIV Integrase Inhibitors - chemistry
HIV Integrase Inhibitors - pharmacology
HIV-1
HIV-1 - drug effects
HIV-1 - physiology
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Intercellular Signaling Peptides and Proteins
Intercellular Signaling Peptides and Proteins - metabolism
Medical sciences
Pharmacology. Drug treatments
Protein Multimerization
Pyrrolidinones - pharmacology
Quinolines
Quinolines - chemistry
Quinolines - pharmacology
Raltegravir Potassium
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virus Integration
Virus Integration - drug effects
Virus Replication - drug effects
Immunopathology
Retroviridae
AIDS
Binding site
Immune deficiency
Lentivirus
Infection
Virus
Viral disease
Replication
Inhibitor
Small molecule
Human immunodeficiency virus
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
Bibliography:F.C. and S.S. contributed equally to this work.
Present address: Scott Butler, AstraZeneca, Waltham, MA, USA; Stephen Shaw and Chris Pickford, The Research Network, Sandwich, United Kingdom; Mike Westby, Loxbridge Research LLC, London, United Kingdom.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.00717-12