Biochemical Studies on the Mechanism of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Resistance to 1-(β-d-Dioxolane)Thymine Triphosphate

• Published in: Antimicrobial Agents and Chemotherapy Vol. 51; no. 6; pp. 2078 - 2084
• Main Authors: LENNERSTRAND, Johan, CHU, Chung K, SCHINAZI, Raymond F
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.06.2007
• Subjects: Anti-HIV Agents; Anti-HIV Agents - chemistry; Anti-HIV Agents - pharmacology; Anti-HIV Agents/chemistry/pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Biological and medical sciences; Dioxolanes; Dioxolanes - chemistry; Dioxolanes - pharmacology; Dioxolanes/chemistry/pharmacology; Drug Resistance, Viral; Drug Resistance, Viral - genetics; HIV Reverse Transcriptase; HIV Reverse Transcriptase - antagonists & inhibitors; HIV Reverse Transcriptase - genetics; HIV Reverse Transcriptase - metabolism; HIV Reverse Transcriptase/antagonists & inhibitors/genetics/metabolism; HIV-1; HIV-1 - drug effects; HIV-1 - enzymology; HIV-1 - genetics; HIV-1/drug effects/enzymology/genetics; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Medical sciences; MEDICIN; MEDICINE; Microbial Sensitivity Tests; Mutation; Pharmacology. Drug treatments; Reverse Transcriptase Inhibitors; Reverse Transcriptase Inhibitors - pharmacology; Thymine Nucleotides; Thymine Nucleotides - chemistry; Thymine Nucleotides - pharmacology; Thymine Nucleotides/chemistry/pharmacology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Immunopathology; RNA-directed DNA polymerase; HIV-1 virus; Enzyme; Transferases; Thymine; Retroviridae; Reverse transcription; AIDS; Biochemistry; Immune deficiency; Lentivirus; Infection; Virus; Resistance; Nucleotidyltransferases; Viral disease; Human immunodeficiency virus; Mechanism of action; Viral/genetics; Drug Resistance
• ISSN: 0066-4804; 1098-6596; 1098-6596
• DOI: 10.1128/AAC.00119-07

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