Impact of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations P119S and T165A on 4′-Ethynylthymidine Analog Resistance Profile

• Published in: Antimicrobial Agents and Chemotherapy Vol. 53; no. 11; pp. 4640 - 4646
• Main Authors: Yang, Guangwei, Paintsil, Elijah, Dutschman, Ginger E, Grill, Susan P, Wang, Chuan-Jen, Wang, Jimin, Tanaka, Hiromichi, Hamasaki, Takayuki, Baba, Masanori, Cheng, Yung-Chi
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.11.2009; American Society for Microbiology (ASM)
• Subjects: Anti-HIV Agents; Anti-HIV Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Biological and medical sciences; Computer Simulation; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV Reverse Transcriptase - genetics; HIV-1; HIV-1 - drug effects; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Medical sciences; Microbial Sensitivity Tests; Mutation; Pharmacology. Drug treatments; Reverse Transcriptase Inhibitors - pharmacology; Stavudine; Stavudine - analogs & derivatives; Stavudine - pharmacology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Immunopathology; RNA-directed DNA polymerase; HIV-1 virus; Enzyme; Transferases; Retroviridae; Reverse transcription; AIDS; Reverse mutation; Immune deficiency; Lentivirus; Profile; Infection; Virus; Resistance; Nucleotidyltransferases; Viral disease; Analog; Human immunodeficiency virus
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.00686-09

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