Early Metacarpal Bone Mineral Density Loss Using Digital X-Ray Radiogrammetry and 3-Tesla Wrist MRI in Established Rheumatoid Arthritis: A Longitudinal One-Year Observational Study

Objectives. Early change in rheumatoid arthritis (RA) is characterised by periarticular osteopenia. We investigated the relationship of early metacarpal digital X-ray radiogrammetry bone mineral density (DXR-BMD) change rate (RC-BMD, mg/cm2/month) to longitudinal changes in hand and feet radiographi...

Full description

Saved in:
Bibliographic Details
Published inArthritis Vol. 2015; pp. 852989 - 8
Main Authors Rastogi, Anshul, Algulin, Jakob, Mangat, Pamela, Lim, Adrian K. P., Satchithananda, Keshthra, Hajnal, Joseph V., Taylor, Peter C.
Format Journal Article
LanguageEnglish
Published United States Hindawi Limiteds 01.01.2015
Hindawi Publishing Corporation
Hindawi Limited
Subjects
Automation
Biomedical research
Bone density
Bones
Clinical medicine
Colleges & universities
Density
Diagnosis
Funding
Hospitals
Hypotheses
Magnetic resonance imaging
Physiological aspects
Prognosis
Proteins
Rheumatoid arthritis
Rheumatology
Wrist
United Kingdom
United Kingdom > UK
Online AccessGet full text

Cover

More Information
Summary:Objectives. Early change in rheumatoid arthritis (RA) is characterised by periarticular osteopenia. We investigated the relationship of early metacarpal digital X-ray radiogrammetry bone mineral density (DXR-BMD) change rate (RC-BMD, mg/cm2/month) to longitudinal changes in hand and feet radiographic and wrist MRI scores over 1 year. Materials and Methods. 10 RA patients completed the study and had wrist 3T-MRI and hand and feet X-rays at various time points over 1 year. MRI was scored by RAMRIS, X-ray was done by van der Heijde modified Sharp scoring, and RC-BMD was analysed using dxr-online. Results. There was good correlation amongst the two scorers for MRI measures and ICC for erosions: 0.984, BME: 0.943, and synovitis: 0.657. Strong relationships were observed between RC-BMD at 12-week and 1-year change in wrist marrow oedema (BME) (r=0.78, P=0.035) but not with erosion, synovitis, or radiographic scores. Conclusion. Early RC-BMD correlates with 1-year wrist BME change, which is a known predictor of future erosion and joint damage. However, in our pilot study, early RC-BMD did not show relationships to MRI erosion or radiographic changes over 1 year. This may reflect a slower kinetic in the appearance of MRI/radiographic erosions, generating the hypothesis that RC-BMD may be a more sensitive and early structural prognostic marker in RA follow-up.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Marco Amedeo Cimmino
ISSN:2090-1984
2090-1992
DOI:10.1155/2015/852989