Polymerization-Induced Self-Assembly of Galactose-Functionalized Biocompatible Diblock Copolymers for Intracellular Delivery

Recent advances in polymer science are enabling substantial progress in nanobiotechnology, particularly in the design of new tools for enhanced understanding of cell biology and for smart drug delivery formulations. Herein, a range of novel galactosylated diblock copolymer nano-objects is prepared d...

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Published inJournal of the American Chemical Society Vol. 135; no. 36; pp. 13574 - 13581
Main Authors Ladmiral, Vincent, Semsarilar, Mona, Canton, Irene, Armes, Steven P.
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 11.09.2013
Subjects
Addition polymerization
Biocompatibility
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacokinetics
Cell Survival
Cells, Cultured
Chemical Sciences
Copolymers
Drug Delivery Systems
Galactose - chemistry
Humans
Micelles
Microscopy, Fluorescence
Molecular Structure
Nanostructure
Polymerization
Polymers
Polymers - chemical synthesis
Polymers - chemistry
Polymers - pharmacokinetics
Self assembly
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Summary:Recent advances in polymer science are enabling substantial progress in nanobiotechnology, particularly in the design of new tools for enhanced understanding of cell biology and for smart drug delivery formulations. Herein, a range of novel galactosylated diblock copolymer nano-objects is prepared directly in concentrated aqueous solution via reversible addition–fragmentation chain transfer polymerization using polymerization-induced self-assembly. The resulting nanospheres, worm-like micelles, or vesicles interact in vitro with galectins as judged by a turbidity assay. In addition, galactosylated vesicles are highly biocompatible and allow intracellular delivery of an encapsulated molecular cargo.
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PMCID: PMC3798098
ISSN:0002-7863
1520-5126
DOI:10.1021/ja407033x