Functional Gold Nanoparticles as Potent Antimicrobial Agents against Multi-Drug-Resistant Bacteria

• Published in: ACS nano Vol. 8; no. 10; pp. 10682 - 10686
• Main Authors: Li, Xiaoning, Robinson, Sandra M, Gupta, Akash, Saha, Krishnendu, Jiang, Ziwen, Moyano, Daniel F, Sahar, Ali, Riley, Margaret A, Rotello, Vincent M
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 28.10.2014
• Subjects: Anti-Bacterial Agents - pharmacology; Antiinfectives and antibacterials; Bacteria; Drug Resistance, Multiple, Bacterial; Escherichia coli; Gold; Gold - chemistry; Metal Nanoparticles; MRSA; Nanoparticles; Pathogens; Toxicity; Tuning; MDR E. coli; uropathogens; antimicrobial agents; mode of action; gold nanoparticles; MRSA; structure−activity relationship

We present the use of functionalized gold nanoparticles (AuNPs) to combat multi-drug-resistant pathogenic bacteria. Tuning of the functional groups on the nanoparticle surface provided gold nanoparticles that were effective against both Gram-negative and Gram-positive uropathogens, including multi-d...