Functional Gold Nanoparticles as Potent Antimicrobial Agents against Multi-Drug-Resistant Bacteria

We present the use of functionalized gold nanoparticles (AuNPs) to combat multi-drug-resistant pathogenic bacteria. Tuning of the functional groups on the nanoparticle surface provided gold nanoparticles that were effective against both Gram-negative and Gram-positive uropathogens, including multi-d...

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Bibliographic Details
Published inACS nano Vol. 8; no. 10; pp. 10682 - 10686
Main Authors Li, Xiaoning, Robinson, Sandra M, Gupta, Akash, Saha, Krishnendu, Jiang, Ziwen, Moyano, Daniel F, Sahar, Ali, Riley, Margaret A, Rotello, Vincent M
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 28.10.2014
Subjects
Anti-Bacterial Agents - pharmacology
Antiinfectives and antibacterials
Bacteria
Drug Resistance, Multiple, Bacterial
Escherichia coli
Gold
Gold - chemistry
Metal Nanoparticles
MRSA
Nanoparticles
Pathogens
Toxicity
Tuning
MDR E. coli
uropathogens
antimicrobial agents
mode of action
gold nanoparticles
MRSA
structure−activity relationship
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Summary:We present the use of functionalized gold nanoparticles (AuNPs) to combat multi-drug-resistant pathogenic bacteria. Tuning of the functional groups on the nanoparticle surface provided gold nanoparticles that were effective against both Gram-negative and Gram-positive uropathogens, including multi-drug-resistant pathogens. These AuNPs exhibited low toxicity to mammalian cells, and bacterial resistance was not observed after 20 generations. A strong structure–activity relationship was observed as a function of AuNP functionality, providing guidance to activity prediction and rational design of effective antimicrobial nanoparticles.
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ISSN:1936-0851
1936-086X
1936-086X
DOI:10.1021/nn5042625