Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae: Contribution of the FCY2, FCY1, and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance

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Published inAntimicrobial Agents and Chemotherapy Vol. 51; no. 1; pp. 369 - 371
Main Authors PAPON, Nicolas, NOËL, Thierry, FLORENT, Martine, GIBOT-LECLERC, Stephanie, JEAN, Dorothée, CHASTIN, Christiane, VILLARD, Jean, CHAPELAND-LECLERC, Florence
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.01.2007
Subjects
Alleles
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal Agents
Antifungal Agents - pharmacology
Biological and medical sciences
Candida
Candida - drug effects
Candida - enzymology
Candida - genetics
Candida lusitaniae
Cloning, Molecular
Cytosine Deaminase
Cytosine Deaminase - genetics
DNA, Fungal
DNA, Fungal - chemistry
DNA, Fungal - genetics
Drug Resistance, Fungal
Drug Resistance, Fungal - genetics
Fluconazole
Fluconazole - pharmacology
Flucytosine
Flucytosine - pharmacology
Fluorouracil
Fluorouracil - pharmacology
Fungal Proteins
Fungal Proteins - genetics
Genetic Complementation Test
Life Sciences
Mechanisms of Resistance
Medical sciences
Microbial Sensitivity Tests
Microbiology and Parasitology
Molecular Sequence Data
Mutation
Pentosyltransferases
Pentosyltransferases - genetics
Pharmacology. Drug treatments
Plasmids
Plasmids - genetics
Sequence Analysis, DNA
Antineoplastic agent
Candidiasis
Yeast
Mycosis
Fungi
Antifungal agent
Gene
Genetics
Cross resistance
Fungi Imperfecti
Mechanism of action
Thallophyta
Fluorouracil
Fluconazole
Enzyme
Fluoropyrimidine derivatives
Transferases
Enzyme inhibitor
Thymidylate synthase
Infection
Antimetabolic
Methyltransferases
Candida
Triazole derivatives
Flucytosine
Pyrimidine derivatives
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Abstract Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
AbstractList ABSTRACT Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.
Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.
Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two patterns of resistance to flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil, whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory flucytosine concentrations.
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Author Stéphanie Gibot-Leclerc
Jean Villard
Thierry Noël
Nicolas Papon
Florence Chapeland-Leclerc
Dorothée Jean
Christiane Chastin
Martine Florent
AuthorAffiliation Laboratoire des Sciences Végétales, EA209, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris 5, 4 avenue de l'Observatoire, 75006 Paris, France, 1 Laboratoire de Mycologie Moléculaire, UMR 5162 CNRS-Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France 2
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10.1128/AAC.47.4.1275-1284.2003
10.1128/CMR.12.1.40
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Issue 1
Keywords Antineoplastic agent
Candidiasis
Yeast
Mycosis
Fungi
Antifungal agent
Gene
Genetics
Cross resistance
Fungi Imperfecti
Mechanism of action
Thallophyta
Fluorouracil
Fluconazole
Enzyme
Fluoropyrimidine derivatives
Transferases
Enzyme inhibitor
Thymidylate synthase
Infection
Antimetabolic
Methyltransferases
Candida
Triazole derivatives
Flucytosine
Pyrimidine derivatives
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PMCID: PMC1797687
Corresponding author. Mailing address: Laboratoire des Sciences Végétales, EA209, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris 5, 4 avenue de l'Observatoire, 75006 Paris, France. Phone: (33) 1 53 73 96 41. Fax: (33) 1 53 73 96 40. E-mail: florence.leclerc@univ-paris5.fr.
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Snippet Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit...
Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two...
ABSTRACT Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae...
Inactivation of the FCY2 (cytosine permease), FCY1 (cytosine deaminase), and FUR1 (uracil phosphoribosyltransferase) genes in Candida lusitaniae produced two...
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SubjectTerms Alleles
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal Agents
Antifungal Agents - pharmacology
Biological and medical sciences
Candida
Candida - drug effects
Candida - enzymology
Candida - genetics
Candida lusitaniae
Cloning, Molecular
Cytosine Deaminase
Cytosine Deaminase - genetics
DNA, Fungal
DNA, Fungal - chemistry
DNA, Fungal - genetics
Drug Resistance, Fungal
Drug Resistance, Fungal - genetics
Fluconazole
Fluconazole - pharmacology
Flucytosine
Flucytosine - pharmacology
Fluorouracil
Fluorouracil - pharmacology
Fungal Proteins
Fungal Proteins - genetics
Genetic Complementation Test
Life Sciences
Mechanisms of Resistance
Medical sciences
Microbial Sensitivity Tests
Microbiology and Parasitology
Molecular Sequence Data
Mutation
Pentosyltransferases
Pentosyltransferases - genetics
Pharmacology. Drug treatments
Plasmids
Plasmids - genetics
Sequence Analysis, DNA
Title Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae: Contribution of the FCY2, FCY1, and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance
URI http://aac.asm.org/content/51/1/369.abstract
https://www.ncbi.nlm.nih.gov/pubmed/17060521
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Volume 51
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