Molecular Mechanism of Flucytosine Resistance in Candida lusitaniae: Contribution of the FCY2, FCY1, and FUR1 Genes to 5-Fluorouracil and Fluconazole Cross-Resistance

• Published in: Antimicrobial Agents and Chemotherapy Vol. 51; no. 1; pp. 369 - 371
• Main Authors: PAPON, Nicolas, NOËL, Thierry, FLORENT, Martine, GIBOT-LECLERC, Stephanie, JEAN, Dorothée, CHASTIN, Christiane, VILLARD, Jean, CHAPELAND-LECLERC, Florence
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.01.2007
• Subjects: Alleles; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents; Antifungal Agents - pharmacology; Biological and medical sciences; Candida; Candida - drug effects; Candida - enzymology; Candida - genetics; Candida lusitaniae; Cloning, Molecular; Cytosine Deaminase; Cytosine Deaminase - genetics; DNA, Fungal; DNA, Fungal - chemistry; DNA, Fungal - genetics; Drug Resistance, Fungal; Drug Resistance, Fungal - genetics; Fluconazole; Fluconazole - pharmacology; Flucytosine; Flucytosine - pharmacology; Fluorouracil; Fluorouracil - pharmacology; Fungal Proteins; Fungal Proteins - genetics; Genetic Complementation Test; Life Sciences; Mechanisms of Resistance; Medical sciences; Microbial Sensitivity Tests; Microbiology and Parasitology; Molecular Sequence Data; Mutation; Pentosyltransferases; Pentosyltransferases - genetics; Pharmacology. Drug treatments; Plasmids; Plasmids - genetics; Sequence Analysis, DNA; Antineoplastic agent; Candidiasis; Yeast; Mycosis; Fungi; Antifungal agent; Gene; Genetics; Cross resistance; Fungi Imperfecti; Mechanism of action; Thallophyta; Fluorouracil; Fluconazole; Enzyme; Fluoropyrimidine derivatives; Transferases; Enzyme inhibitor; Thymidylate synthase; Infection; Antimetabolic; Methyltransferases; Candida; Triazole derivatives; Flucytosine; Pyrimidine derivatives
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.00824-06

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