Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks

• Published in: Mediators of Inflammation Vol. 2006; no. 2; pp. 1 - 5
• Main Authors: TOY, Bülent, TARCIN, Orhan, BAGCI, Sait, ÜSTÜNDAG, Yücel, INAL, Ali, TIFTIKCI, Arzu
• Format: Journal Article
• Language: English
• Published: Sylvania, OH Hindawi Limiteds 01.01.2006; Hindawi; Hindawi Limited; Hindawi Publishing Corporation; Wiley
• Subjects: Adult; Biological and medical sciences; Biomarkers; Blood Sedimentation; C-Reactive Protein - biosynthesis; Care and treatment; Diagnosis; Diseases of the osteoarticular system; Familial Mediterranean fever; Familial Mediterranean Fever - blood; Familial Mediterranean Fever - diagnosis; Female; Fibrinogen - biosynthesis; Health aspects; Humans; Inflammatory joint diseases; Interleukin-6 - blood; Leptin; Leptin - blood; Leukocyte Count; Male; Medical sciences; Research Communication; Human; Leptin; Diseases of the osteoarticular system; Familial recurrent polyseritis; Biological marker; Serum; Diagnosis; Genetic disease
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/MI/2006/62868

The aim of our study is to determine whether there is a relationship between familial Mediterranean fever (FMF) attacks and serum leptin levels. We enrolled 25 patients (22 males and 3 females) and 25 healthy controls (21 males and 4 females) with a mean age of 24.42 +/- 1.22 (Mean +/- SEM) years and 24.30 +/- 1.19 years (Mean +/- SEM), respectively. We investigated serum levels of leptin, interleukin-6 (IL-6) erythrocyte sedimentation rate (ESR), C-reactive protein (CRP),fibrinogen, and leukocyte counts before the attack and 8-12 hours after the attack started. The same parameters have been investigated in the control subjects. The mean serum leptin levels before the attacks were 6.45 +/- 1.05 (Mean +/- SEM) and during the attacks were 7.59 +/- 1.3 (Mean +/- SEM) in FMF group,respectively. There was a slight increase in serum leptin levels during the attacks but it was not statistically significant (P > .05). The mean serum leptin levels were 16.12 +/- 2.81 in the control group which were not different from the mean serum leptin levels before and during the attack periods in the study group (P > .05). However, there were statistical differences in the serum levels of IL-6, ESR, CRP, fibrinogen, and leukocyte counts before and during the attack periods (P > .05). No correlation was found between serum leptin levels and IL-6, ESR, CRP, fibrinogen, and leukocyte counts (P > .05). Serum leptin levels do not increase during FMF attacks and therefore it is not useful for diagnostic purposes and follow-up during treatment.