Self-Assembly of Peptide Bioconjugates: Selected Recent Research Highlights

• Published in: Bioconjugate chemistry Vol. 28; no. 3; pp. 731 - 739
• Main Authors: Hamley, Ian W, Castelletto, Valeria
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.03.2017
• Subjects: Animals; Biocompatible Materials - chemistry; Biocompatible Materials - metabolism; Biopolymers; Enzymes; Humans; Kinetics; Models, Molecular; Peptides; Peptides - chemistry; Peptides - metabolism; Polymers; Polymers - chemistry; Polymers - metabolism; Surface-Active Agents - chemistry; Surface-Active Agents - metabolism; Tissue Scaffolds - chemistry; Topical Review
• ISSN: 1043-1802; 1520-4812; 1520-4812
• DOI: 10.1021/acs.bioconjchem.6b00284

This Topical Review briefly discusses selected highlights of recent research on self-assembling peptide amphiphiles (PAs) and polymer–peptide conjugates. Subjects covered include new polymer chemistries used to prepare polymer–peptide conjugates, PA self-assembly landscapes and kinetics, developments in the application of bioactive PAs and the relationship between self-assembly and bioactivity, novel PA/biopolymer composites, functional π-stacking peptide conjugates, use of enzymes to tune self-assembly, and developments in high throughput methods and the design and application of sequenced peptides.