Impact of diet change on the gut microbiome of common marmosets ( Callithrix jacchus )

• Published in: mSystems Vol. 9; no. 8; p. e0010824
• Main Authors: Tang-Wing, Cassandra, Mohanty, Ipsita, Bryant, MacKenzie, Makowski, Katherine, Melendez, Daira, Dorrestein, Pieter C., Knight, Rob, Caraballo-Rodríguez, Andrés Mauricio, Allaband, Celeste, Jenné, Keith
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 20.08.2024
• Subjects: Animals; Bifidobacterium; Bifidobacterium - isolation & purification; Cadaverine; Callithrix - microbiology; Callithrix jacchus; Captivity; Diet; Diet - veterinary; Dietary supplements; Feces; Feces - microbiology; Female; Females; Gastrointestinal diseases; Gastrointestinal Microbiome - physiology; Gut microbiota; Host-Microbial Interactions; Inflammatory bowel disease; Intestinal microflora; Intestine; Male; Males; Metabolism; Metabolites; metabolome; Metabolomics; Metagenomics; microbiome; Microbiomes; nutrition; Nutrition research; physiology; Probiotics; Putrescine; Reabsorption; Research Article; Species; veterinary microbiology; Weight control; United States > US; primate; nutrition; nonhuman microbiome; veterinary microbiology; metagenomics; physiology; marmoset; microbiome; metabolome; nonhuman microbiota
• ISSN: 2379-5077; 2379-5077
• DOI: 10.1128/msystems.00108-24

Appropriate diet and health of the common marmoset in captivity are essential both for the welfare of the animal and to improve experimental outcomes. Our study shows that a gel diet compared to a biscuit diet improves the health of a marmoset colony, is linked to increases in Bifidobacterium species, and increases the removal of molecules associated with disease. The diet transition had an influence on the molecular changes at both the pair and time point group levels, but only at the pair level for the microbial changes. It appears to be more important which genes and functions present changed rather than specific microbes. Further studies are needed to identify specific components that should be considered when choosing an appropriate diet and additional supplementary foods, as well as to validate the benefits of providing probiotics. Probiotics containing Bifidobacterium species appear to be useful as probiotic supplements to the laboratory marmoset diet, but additional work is needed to validate these findings.