Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

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Published inAntimicrobial Agents and Chemotherapy Vol. 44; no. 4; pp. 853 - 858
Main Authors PLACIDI, L, CRETTON-SCOTT, E, GOSSELIN, G, PIERRA, C, SCHINAZI, R. F, IMBACH, J.-L, EL KOUNI, M. H, SOMMADOSSI, J.-P
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.04.2000
Subjects
2',3'-Dideoxyadenosine
Adenosine - analogs & derivatives
Adenosine - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents
Antiviral Agents - metabolism
Antiviral Agents - pharmacology
Biological and medical sciences
Cell Line
Cells, Cultured
Chromatography, High Pressure Liquid
Cryopreservation
Dideoxyadenosine
Dideoxyadenosine - metabolism
Dideoxyadenosine - pharmacology
Hepatitis B virus
Hepatitis B virus - drug effects
HepG2 cells
HIV - drug effects
Human immunodeficiency virus
Humans
Liver - cytology
Liver - metabolism
Medical sciences
methylthioadenosine phosphorylase
Monocytes - metabolism
Pharmacology. Drug treatments
Thionucleosides - pharmacology
Phosphorylation
Enzyme
Digestive system
Metabolite
Transferases
Liver
Glycosyltransferases
Orthohepadnavirus
Retroviridae
Metabolism
Lentivirus
Deoxyadenosine
In vitro
Biological activity
Virus
Mononuclear cell
5'-Methylthioadenosine phosphorylase
Hepatocyte
Hepadnaviridae
Established cell line
Antiviral
Hepatitis B virus
Human immunodeficiency virus
Pentosyltransferases
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
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Corresponding author. Mailing address: Department of Pharmacology, University of Alabama at Birmingham, 1670 University Blvd., Volker Hall G019, Birmingham, AL 35294.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.44.4.853-858.2000