An Obesity-Related FTO Variant and the Risk of Preeclampsia in a Finnish Study Population

• Published in: Journal of Pregnancy Vol. 2011; no. 2011; pp. 71 - 77
• Main Authors: Heino, Sanna, Klemetti, Miira, Laivuori, Hannele, Kajantie, Eero, Heinonen, Seppo, Hiltunen, Leena M.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01.01.2011; Hindawi Puplishing Corporation; Hindawi Publishing Corporation; Hindawi Limited
• Subjects: Adult; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Analysis of Variance; Body Mass Index; Case-Control Studies; Chi-Square Distribution; Female; Finland; Genotype; Humans; Obesity - complications; Obesity - genetics; Polymorphism, Single Nucleotide; Pre-Eclampsia - genetics; Pregnancy; Proteins - genetics; Risk Factors; Statistics, Nonparametric; Young Adult
• ISSN: 2090-2727; 2090-2735
• DOI: 10.1155/2011/251470

Previous studies have demonstrated a common variant of the obesity and fat mass-related FTO gene, rs9939609, to be associated with obesity, type 2 diabetes, and elevated blood pressure. We investigated whether the FTO SNP rs9939609 is associated with the risk of preeclampsia (PE) in a Finnish study population. 485 women with prior PE and 449 women who had given birth after a normotensive pregnancy were genotyped (TaqMan) for the SNP rs9939609. The prevalences of genotypes AA, AT, and TT were 15%, 53%, and 32%, respectively, among the PE cases, and 16%, 47%, and 37%, respectively, among the controls (P=0.199). We found no evidence of an association between the FTO SNP rs9939609 and PE. However, our cases were dominated by severe, early-onset PE. Thus, we are unable to exclude an association with the milder, later-onset form of the disease in which the role of maternal metabolic predisposition could be more significant.Erratum to “An Obesity-Related FTO Variant and the Risk of Preeclampsia in a Finnish Study Population”dx.doi.org/10.1155/2012/540682