Formation Mechanism of NDMA from Ranitidine, Trimethylamine, and Other Tertiary Amines during Chloramination: A Computational Study

• Published in: Environmental science & technology Vol. 48; no. 15; pp. 8653 - 8663
• Main Authors: Liu, Yong Dong, Selbes, Meric, Zeng, Chengchu, Zhong, Rugang, Karanfil, Tanju
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 05.08.2014
• Subjects: Amines - chemistry; Carcinogens; Chloramines; Dimethylnitrosamine - chemical synthesis; Disinfection; Disinfection & disinfectants; Drinking water; Drinking Water - chemistry; Methylamines - chemistry; Organic chemicals; Pharmaceutical Preparations - chemistry; Prescription drugs; Ranitidine - chemistry
• ISSN: 0013-936X; 1520-5851
• DOI: 10.1021/es500997e

Chloramination of drinking waters has been associated with N-nitrosodimethylamine (NDMA) formation as a disinfection byproduct. NDMA is classified as a probable carcinogen and thus its formation during chloramination has recently become the focus of considerable research interest. In this study, the formation mechanisms of NDMA from ranitidine and trimethylamine (TMA), as models of tertiary amines, during chloramination were investigated by using density functional theory (DFT). A new four-step formation pathway of NDMA was proposed involving nucleophilic substitution by chloramine, oxidation, and dehydration followed by nitrosation. The results suggested that nitrosation reaction is the rate-limiting step and determines the NDMA yield for tertiary amines. When 45 other tertiary amines were examined, the proposed mechanism was found to be more applicable to aromatic tertiary amines, and there may be still some additional factors or pathways that need to be considered for aliphatic tertiary amines. The heterolytic ONN­(Me)2–R+ bond dissociation energy to release NDMA and carbocation R+ was found to be a criterion for evaluating the reactivity of aromatic tertiary amines. A structure–activity study indicates that tertiary amines with benzyl, aromatic heterocyclic ring, and diene-substituted methenyl adjacent to the DMA moiety are potentially significant NDMA precursors. The findings of this study are helpful for understanding NDMA formation mechanism and predicting NDMA yield of a precursor.