Areas of Brain Damage Underlying Increased Reports of Behavioral Disinhibition

Disinhibition, the inability to inhibit inappropriate behavior, is seen in frontal-temporal degeneration, Alzheimer’s disease, and stroke. Behavioral disinhibition leads to social and emotional impairments, including impulsive behavior and disregard for social conventions. The authors investigated t...

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Published inThe journal of neuropsychiatry and clinical neurosciences Vol. 27; no. 3; pp. 193 - 198
Main Authors Knutson, Kristine M, Dal Monte, Olga, Schintu, Selene, Wassermann, Eric M, Raymont, Vanessa, Grafman, Jordan, Krueger, Frank
Format Journal Article
LanguageEnglish
Published United States American Psychiatric Association 01.07.2015
Subjects
Brain - diagnostic imaging
Brain - pathology
Brain Injuries - pathology
Brain Injuries - psychology
Brain Mapping
Humans
Inhibition, Psychological
Intelligence Tests
Male
Middle Aged
Neuropsychological Tests
Radiography
Tomography Scanners, X-Ray Computed
Veterans
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Summary:Disinhibition, the inability to inhibit inappropriate behavior, is seen in frontal-temporal degeneration, Alzheimer’s disease, and stroke. Behavioral disinhibition leads to social and emotional impairments, including impulsive behavior and disregard for social conventions. The authors investigated the effects of lesions on behavioral disinhibition measured by the Neuropsychiatric Inventory in 177 veterans with traumatic brain injuries. The authors performed voxel-based lesion-symptom mapping using MEDx. Damage in the frontal and temporal lobes, gyrus rectus, and insula was associated with greater behavioral disinhibition, providing further evidence of the frontal lobe’s involvement in behavioral inhibition and suggesting that these regions are necessary to inhibit improper behavior.
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ISSN:0895-0172
1545-7222
1545-7222
DOI:10.1176/appi.neuropsych.14060126