New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19

• Published in: Antimicrobial agents and chemotherapy Vol. 65; no. 1
• Main Authors: Aleissa, Muneerah M, Silverman, Emily A, Paredes Acosta, Luisa M, Nutt, Cameron T, Richterman, Aaron, Marty, Francisco M
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 16.12.2020
• Subjects: Adenosine Monophosphate - administration & dosage; Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - chemistry; Adenosine Monophosphate - pharmacokinetics; Adenosine Monophosphate - pharmacology; Alanine - administration & dosage; Alanine - analogs & derivatives; Alanine - chemistry; Alanine - pharmacokinetics; Alanine - pharmacology; Animals; Antiviral Agents - administration & dosage; Antiviral Agents - chemistry; Antiviral Agents - pharmacokinetics; Antiviral Agents - pharmacology; Breast Feeding; Clinical Trials as Topic; Coronavirus Infections - drug therapy; Coronavirus Infections - prevention & control; COVID-19; COVID-19 - drug therapy; Editor's Pick; Female; Humans; Immunocompromised Host; Middle East Respiratory Syndrome Coronavirus - drug effects; Perspective; Pregnancy; SARS-CoV-2 - drug effects; SARS-CoV-2 - genetics; COVID-19; SARS-CoV-2; remdesivir; antiviral
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.01814-20

Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Preclinical data in animal models of coronavirus diseases, including COVID-19, have demonstrated that early treatment with remdesivir leads to improved survival, decreased lung injury, and decreased levels of viral RNA. Recent clinical data have demonstrated the clinical activity of remdesivir in terms of faster time to recovery in patients with severe COVID-19 and higher odds of improved clinical status in patients with moderate COVID-19. Here, clinical trials published to date are presented and appraised. Remdesivir's potential benefits and its favorable adverse-event profile make it an option for the treatment of COVID-19. This article examines the available literature describing remdesivir's pharmacology, pharmacokinetics, and preclinical and clinical data.