In vivo activity and pharmacodynamics of amoxicillin in combination with fosfomycin in fibrin clots infected with highly penicillin-resistant Streptococcus pneumoniae

• Published in: Antimicrobial Agents and Chemotherapy Vol. 40; no. 9; pp. 2062 - 2066
• Main Authors: CHAVANET, P, PEYRARD, N, PECHINOT, A, BUISSON, M, DUONG, M, NEUWIRTH, C, KAZMIERCZAK, A, PORTIER, H
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.09.1996
• Subjects: Amoxicillin - pharmacokinetics; Amoxicillin - pharmacology; Amoxicillin - therapeutic use; Animals; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Colony Count, Microbial; Drug Therapy, Combination; Drug Therapy, Combination - pharmacokinetics; Drug Therapy, Combination - pharmacology; Drug Therapy, Combination - therapeutic use; Fibrin; Fibrin - metabolism; Fosfomycin - pharmacokinetics; Fosfomycin - pharmacology; Fosfomycin - therapeutic use; Half-Life; Humans; Medical sciences; Penicillin Resistance; Penicillins - pharmacokinetics; Penicillins - pharmacology; Penicillins - therapeutic use; Pharmacology. Drug treatments; Pneumococcal Infections; Pneumococcal Infections - drug therapy; Pneumococcal Infections - microbiology; Rabbits; Research Support, Non-U.S. Gov't; Streptococcus pneumoniae; Streptococcus pneumoniae - drug effects; Drug combination; Rabbit; Lagomorpha; Clot; Streptococcus pneumoniae; Infection; Penicillin derivatives; Streptococcaceae; Fibrin; Vertebrata; Antibiotic; Chemotherapy; Mammalia; Treatment; Animal; Bacteria; Micrococcales; Antibacterial agent
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.40.9.2062

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