Investigation on the Anticancer Activity of Symmetric and Unsymmetric Cyclic Sulfamides

The sulfamide functional group has been extensively employed in organic synthesis to discover probes and drugs in various applications such as cancer, human immunodeficiency virus (HIV), virus, and diabetes. Herein, we describe the synthesis of 7-membered symmetric and unsymmetric sulfamide compound...

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Published inACS medicinal chemistry letters Vol. 12; no. 2; pp. 202 - 210
Main Authors Jun, Jaden Jungho, Duscharla, Divya, Ummanni, Ramesh, Hanson, Paul R, Malhotra, Sanjay V
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 11.02.2021
Amer Chemical Soc
Subjects
Chemistry, Medicinal
Letter
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Science & Technology
NCI-60 cell line
Cyclic sulfamide
A549 lung cancer
Anticancer activity
THERAPEUTIC APPLICATIONS
YM-60828 DERIVATIVES
POTENT
DESIGN
BIOLOGICAL-ACTIVITY
HIV-1 PROTEASE
INHIBITORY PROPERTIES
BINDING
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Summary:The sulfamide functional group has been extensively employed in organic synthesis to discover probes and drugs in various applications such as cancer, human immunodeficiency virus (HIV), virus, and diabetes. Herein, we describe the synthesis of 7-membered symmetric and unsymmetric sulfamide compounds and their biological evaluation through the National Cancer Institute (NCI) panel of 60 human tumor cell lines (NCI-60) and the mechanism of action study. The results of a study from the NCI-60 cell line exhibited that many synthesized cyclic sulfamide compounds inhibited breast cancer (MDA-MB-468). The mechanism of action study of a representative compound 18 showed the inhibition of proliferation and apoptosis in A549 lung cancer cells.
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ISSN:1948-5875
1948-5875
DOI:10.1021/acsmedchemlett.0c00460